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PT-141, also called Bremelanotide, is a heavily modified synthetic derivative of alpha-melanocyte-stimulating hormone. It has been tested in clinical trials as a treatment for both male/female hypoactive sexual desire disorder and acute hemorrhage. PT-141 is an agonist for the melanocortin-4 and melanocortin-1 receptors. Research shows that it promotes sexual arousal and stimulates the immune system.
| Name | PT-141 (Bremelanotide) |
|---|---|
| Sequence | Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH |
| CAS No. | 121062-08-6 |
| Purity | 99% |
| Appearance | Lyophilized Powder |
| Molecular Formula | C50H68N14O10 |
| Molecular Weight | 1025.18 g/mol |
| Storage | Store in an air-tight container away from light at 2-8°C. For best preservation, store below -10°C. |
PT-141, also called bremelanotide, was previously investigated in phase Ilb human clinical trials for use in treating female hypoactive sexual desire disorder (HSDD). PT-141 is a melanocortin that binds primarily to melanocortin 4 receptor (MC-4R) and MC-1R. In 2009, PT-141 was also investigated as a treatment for acute hemorrhage. PT-141 is a derivative of another synthetic melanocortin, Melanotan 2 (MT-2).
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