Menu
P21 is a nootropic peptide targeting improved neurogenesis. In animal studies, P21 has been shown to boost levels of BDNF (brain-derived neurotrophic factor), thus promoting neurogenesis (nerve growth) and inhibiting the formation of Amyloid plaques and Tau proteins seen in Alzheimer’s disease. BDNF has been linked not just to enhanced neurogenesis, but to the down regulation of certain enzyme responsible for tau and amyloid plaque formation in Alzheimer’s brains. P21 has been shown to improve cognition in animal models.
| Name | P21 |
|---|---|
| Sequence | Ac-DGGL-Adamantane-NH2 |
| CAS No. | 1394011-91-6 |
| Purity | 99% |
| Appearance | Lyophilized Powder |
| Molecular Formula | C20H18ClF6N3O2 |
| Molecular Weight | 481.82 g/mol |
| Storage | Store in an air-tight container away from light at 2-8°C. For best preservation, store below -10°C. |
P21 is a peptide that was developed by reverse engineering Cerebrolysin’s effect using epitope mapping. Researchers found that the main neurogenic and memory enhancing effects of Cerebrolysin were due to its ability to react to human CNTF. So the researchers narrowed their search and found that an 11-mer peptide, labeled peptide 6 (Ac-VGDGGLFEKKL-NH2), enhanced hippocampus-dependent learning and memory, increased neurogenesis, and neuronal plasticity. They then determined the most active sub-sequence in the peptide called peptide 6C (Ac-DGGL-NH2). However, this peptide sequence was shown to have poor blood brain barrier permeability, and was easily broken down by plasma enzymes. To combat this, they added an adamantane moiety to the N-terminus of the peptide sequence. This highly lipophilic tricyclic alkane greatly increased the BBB permeability, and protected the peptide from enzymatic degradation. This made the new peptide able to be active when taken via subcutaneous administration. That is how P21 (Ac-DGGL^A-NH2) was born.
Source from NCBI
Providing Premium Peptide for R&D
We will get back to you within one working day, please pay attention to the email “ @vitacodepeptide.com”.
Feel free to contact me, and I will be more than happy to answer all of your questions.
