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KPV is a potent anti-inflammatory peptide that has shown promise in many disease conditions. The most active research is in the treatment of inflammatory bowel disease where the peptide has shown substantial promise. KPV has been shown in animal studies to be safe and effective when administered orally, intravenously, subcutaneously, and transdermal. Research in wound healing also reveals that KPV and other alpha-MSH derivatives may offer a host of benefits that speed wound healing, reduce infection, fight inflammation, and lead to better cosmetic results. KPV and similar peptides could become mainstays not just in wound healing, but in scar reduction following surgery.
| Name | KPV (ACTH(11-13) α-MSH) |
|---|---|
| Sequence | Lys-Pro-Val |
| CAS No. | 67727-97-3 |
| Purity | 99% |
| Appearance | Lyophilized Powder |
| Molecular Formula | C16H30N4O4 |
| Molecular Weight | 342.43 g/mol |
| Storage | Store in an air-tight container away from light at 2-8°C. For best preservation, store below -10°C. |
KPV is the C-terminal peptide fragment of alpha-melanocyte stimulating hormone (alpha-MSH). It is one of many short peptide derivatives of alpha-MSH that has been tested to determine if they retain similar photoprotective properties, activity against ischemia, sexual effects, or benefits on feeding behavior and energy homeostasis. KPV, which is made up of lysine-proline-valine turns out to have significant anti-inflammatory effects.
The peptide is under active research as a potential therapeutic in the treatment of inflammatory bowel disease. It has shown evidence of potent anti-inflammatory activity in the central nervous system, GI tract, lungs, vascular system, and joints. Because KPV is a small peptide, it can be administered in multiple ways including oral, intravenous, and transdermal routes.
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