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Humanin is a naturally occurring micro-peptide found in mitochondria. It protects cells from apoptosis and may be useful in staving off heart, eye, brain, and muscle diseases. Humanin is one of a select, small class of compounds targeting mitochondrial function and thus improving cellular energy efficiency and homeostasis
| Name | Humanin |
|---|---|
| Sequence | Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Ser-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala |
| CAS No. | 330936-69-1 |
| Purity | 99% |
| Appearance | Lyophilized Powder |
| Molecular Formula | C119H204N34O32S2 |
| Molecular Weight | 2687.30 g/mol |
| Storage | Store in an air-tight container away from light at 2-8°C. For best preservation, store below -10°C. |
Humanin is a naturally occurring micro-peptide unique for the fact that it is encoded in the mitochondrial DNA (mitochondria contain a small amount of DNA that is exclusive only to them). It functions as a cytoprotective protein, protecting cells from the process of apoptosis (programmed cell death) via interference with the normal operation of the Bcl2-associated X protein (Bax). Variations of humanin have been found in many mammals from humans to rats and is highly conserved across species. Research shows that humanin is important in protecting neurons, cardiac tissue, muscle cells, the retina of the eye, and the lining of blood vessels.
Source from NCBI
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