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MT 2 (Melanotan 2) is a synthetic analogue of alpha-melanocyte-stimulating hormone. Developed in the 1980s, Melanotan-2 has been shown to increase sexual arousal, reduce compulsive/addictive behavior, curb hunger, and increase melanin production. Research has shown the peptide to stimulate melanocytes therefore producing increased skin pigmentation.
| Name | MT 2 (Melanotan 2) |
|---|---|
| Sequence | Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2 |
| CAS No. | 121062-08-6 |
| Purity | 99% |
| Appearance | Lyophilized Powder |
| Molecular Formula | C50H69N15O9 |
| Molecular Weight | 1024.18 g/mol |
| Storage | Store in an air-tight container away from light at 2-8°C. For best preservation, store below -10°C. |
Melanotan 2 (MT-2) is a synthetic version of human alpha-melanocyte-stimulating hormone (a-MSH). It was originally developed in the 1980s, at the University of Arizona, after it was found that a-MSH caused sexual arousal in rodents as well as darkening of the skin. Originally designed as a sunless tanning option, MT-2 was eventually found to have a wide range of effects such as increasing sexual arousal, promoting tanning or skin pigmentation, reducing compulsive behavior, controlling addiction, fighting hunger, reducing glucagon production, and reversing features of autism.
Melanotan 2 and Melanocortin Signaling
Melanotan 2 produces its effects by binding with melanocortin receptors. There are five known melanocortin receptors, each with a different function. MT-2 is known to bind primarily to MC-4R and MC-1R, but also binds weakly to MC-3R.
• MC-1R: Found on melanocytes, stimulation of MC-1R causes darkening of the skin and hair.
• MC-2R: Found in the adrenal glands, MC-2R binding promotes the secretion of adrenal hormones, such as cortisol.
• MC-3R: MC-3R is involved in appetite control and energy regulation, but little else is known about this receptor.
• MC-4R: Stimulation of MC-4R causes changes in feeding and sexual behavior. It also affects male erectile function and energy homeostasis.
• MC-5R: MC-5R is expressed on sweat glands and pancreatic islet cells.
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